Identifying new methods for integer factorization plays an important role in modern information security. Shor’s algorithm is perhaps the most well-known method for integer factorization. An equally powerful model of quantum computing is the adiabatic quantum computing (AQC) model, which can also solve the integer factorization problem. In this work, the authors developed a framework to convert an arbitrary integer factorization problem to an executable Ising model and tested it on the D-Wave 2000Q.